Open AccessElevated Plasma Concentrations of Syndecan-1 Do Not Correlate With Increased Capillary Leakage of 20% Albumin
Author(s) -
Robert G. Hahn,
Markus Zdolsek,
Camilla Krizhanovskii,
Stelia Ntika,
Joachim Zdolsek
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005315
Subject(s) - albumin , medicine , syndecan 1 , glycocalyx , population , chromatography , endocrinology , chemistry , immunology , biochemistry , environmental health , cell
Preclinical experiments show that an inflammatory reaction causes degradation of the endothelial glycocalyx layer and accelerated capillary leakage of albumin and fluid. The hypothesis in the present study was that elevated plasma concentrations of glycocalyx degradation products are associated with greater capillary leakage in humans.