Open AccessNonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses
Author(s) -
Yangfan Zhou,
Yiuka Leung-Pitt,
Hao Deng,
Yang Ren,
Zerong You,
William R. Kem,
Shiqian Shen,
Wei Zhang,
Jianren Mao,
J. A. Jeevendra Martyn
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005274
Subject(s) - medicine , allodynia , neuropathic pain , microglia , anesthesia , spinal cord , hyperalgesia , nociception , agonist , endocrinology , pharmacology , inflammation , receptor , psychiatry
Burn injury (BI) pain consists of inflammatory and neuropathic components and activates microglia. Nicotinic alpha 7 acetylcholine receptors (α7AChRs) expressed in microglia exhibit immunomodulatory activity during agonist stimulation. Efficacy of selective α7AChR agonist GTS-21 to mitigate BI pain and spinal pain-mediators was tested.