Open AccessDexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via α-2 Adrenergic Receptor
Author(s) -
Menghong Sun,
Yuanlin Dong,
Mengzhu Li,
Yiying Zhang,
Feng Liang,
Jiaqiang Zhang,
Sulpicio G. Soriano,
Zhongcong Xie
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005268
Subject(s) - sevoflurane , clonidine , yohimbine , dexmedetomidine , anesthesia , morris water navigation task , agonist , medicine , postsynaptic potential , pharmacology , endocrinology , antagonist , receptor , hippocampus , sedation
Anesthetic sevoflurane induces tau phosphorylation and cognitive impairment in young mice. The underlying mechanism and the targeted interventions remain largely unexplored. We hypothesized that dexmedetomidine and clonidine attenuated sevoflurane-induced tau phosphorylation and cognitive impairment by acting on α-2 adrenergic receptor.