Open AccessPredicting Unacceptable Pain in Cardiac Surgery Patients Receiving Morphine Maintenance and Rescue Doses: A Model-Based Pharmacokinetic-Pharmacodynamic Analysis
Author(s) -
Sebastiaan C. Goulooze,
Elke H. J. Krekels,
Mohammed A. A. Saleh,
Sabine Ahlers,
Pyry A. J. Välitalo,
Eric P. van Dongen,
Ron H. N. van Schaik,
Thomas Hankemeier,
Dick Tibboel,
Catherijne A. J. Knibbe
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005228
Subject(s) - medicine , pharmacodynamics , morphine , anesthesia , dosing , nonmem , pharmacokinetics , analgesic , interquartile range , surgery , pharmacology
Optimal analgesic treatment following cardiac surgery is crucial for both patient comfort and successful postoperative recovery. While knowledge of both the pharmacokinetics and pharmacodynamics of analgesics is required to predict optimal drug dosing, models quantifying the pharmacodynamics are scarce. Here, we quantify the pharmacodynamics of morphine by modeling the need for rescue morphine to treat unacceptable pain in 118 patients after cardiac surgery.