Open AccessRelationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia
Author(s) -
Thomas W. Schnider,
Charles F. Minto,
Talmage D. Egan,
Miodrag Filipovic
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005125
Subject(s) - propofol , medicine , bispectral index , fentanyl , rocuronium , anesthesia , remifentanil , confidence interval , american society of anesthesiologists
Internationally, propofol is commonly titrated by target-controlled infusion (TCI) to maintain a processed electroencephalographic (EEG) parameter (eg, bispectral index [BIS]) within a specified range. The overall variability in propofol target effect-site concentrations (CeT) necessary to maintain adequate anesthesia in real-world conditions is poorly characterized, as are the patient demographic factors that contribute to this variability. This study explored these issues, hypothesizing that the variability in covariate-adjusted propofol target concentrations during BIS-controlled anesthesia would be substantial and that most of the remaining interpatient variability in drug response would be due to random effects, thus suggesting that the opportunity to improve on the Schnider model with further demographic data is limited.