Open AccessAn Observational Study of the Pharmacokinetics of Surgeon-Performed Intercostal Nerve Blockade With Liposomal Bupivacaine for Posterior-Lateral Thoracotomy Analgesia
Author(s) -
William C. Manson,
Randal S. Blank,
Linda W. Martin,
Salome B Alpert,
Tomasz P Dobrzanski,
Eric B. Schneider,
Sarah J. Ratcliffe,
Marcel E. Durieux
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005115
Subject(s) - medicine , interquartile range , anesthesia , intercostal nerves , bupivacaine , pharmacokinetics , thoracotomy , local anesthetic , surgery
Intercostal nerve blocks with liposomal bupivacaine are commonly used for thoracic surgery pain management. However, dose scheduling is difficult because the pharmacokinetics of a single-dose intercostal injection of liposomal bupivacaine has never been investigated. The primary aim of this study was to assess the median time to peak plasma concentration (Tmax) following a surgeon-administered, single-dose infiltration of 266 mg of liposomal bupivacaine as a posterior multilevel intercostal nerve block in patients undergoing posterolateral thoracotomy.