Open AccessMolecular Interaction Between Butorphanol and κ-Opioid Receptor
Author(s) -
Jiafu Ji,
Wen-Zhen Lin,
Amey Vrudhula,
Xi Jin,
Alexei Yeliseev,
John R. Grothusen,
Weiming Bu,
Renyu Liu
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005017
Subject(s) - butorphanol , agonist , pharmacology , medicine , opioid , receptor , hek 293 cells , opioid receptor , internalization
The misuse of opioids stems, in part, from inadequate knowledge of molecular interactions between opioids and opioid receptors. It is still unclear why some opioids are far more addictive than others. The κ-opioid receptor (KOR) plays a critical role in modulating pain, addiction, and many other physiological and pathological processes. Butorphanol, an opioid analgesic, is a less addictive opioid with unique pharmacological profiles. In this study, we investigated the interaction between butorphanol and KOR to obtain insights into the safe usage of this medication.