Open AccessEffects of an Intraoperative Intravenous Bolus Dose of Dexmedetomidine on Remifentanil-Induced Postinfusion Hyperalgesia in Patients Undergoing Thyroidectomy: A Double-Blind Randomized Controlled Trial
Author(s) -
Zhijie Wu,
Junjie Yu,
Qihua Lin,
Huiting Li,
Tianhua Zhang,
Hao Tan,
Wenqian Lin,
Longhui Cao
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005003
Subject(s) - medicine , dexmedetomidine , remifentanil , anesthesia , pacu , bolus (digestion) , thyroidectomy , perioperative , saline , analgesic , placebo , hyperalgesia , loading dose , surgery , sedation , nociception , propofol , alternative medicine , receptor , thyroid , pathology
Consecutive exposure to high-dose remifentanil during anesthesia may induce remifentanil-induced postinfusion hyperalgesia (RPH). Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, may have synergistic effects with opioids and aid in perioperative pain management. In this study, we hypothesized that an intraoperative bolus dose of intravenous dexmedetomidine could alleviate RPH in patients undergoing thyroidectomy under general anesthesia.