Open AccessVoluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats
Author(s) -
Gregory A. Chinn,
Jennifer M. Russell,
Esther Banh,
Saehee C Lee,
Jeffrey W. Sall
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004418
Subject(s) - medicine , hippocampus , isoflurane , environmental enrichment , dentate gyrus , endocrinology , anesthesia
Early life anesthesia exposure results in long-term cognitive deficits in rats. Environmental enrichment consisting of social housing, a stimulating environment, and voluntary exercise can rescue this deficit. We hypothesized that exercise alone is sufficient to rescue the cognitive deficit associated with perinatal anesthesia.