Open AccessRopivacaine Activates Multiple Proapoptotic and Inflammatory Signaling Pathways That Might Subsume to Trigger Epidural-Related Maternal Fever
Author(s) -
Peter Wohlrab,
Stefan Boehme,
Christoph Kaun,
Johann Wojta,
Andreas Spittler,
Leila Saleh,
Martin Knöfler,
Klaus Markstaller,
Klaus Ulrich Klein,
Verena Tretter
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004402
Subject(s) - ropivacaine , proinflammatory cytokine , medicine , oxidative stress , propidium iodide , apoptosis , pharmacology , cell adhesion molecule , inflammation , immunology , biochemistry , biology , programmed cell death
Epidural-related maternal fever (ERMF) is an adverse effect of epidural analgesia during labor and is associated with perinatal and neonatal morbidity. Local anesthetics have been proposed to trigger ERMF via sterile inflammation. Ropivacaine is currently the most frequently used epidural anesthetic and considered least toxic. This study investigates molecular effects of ropivacaine on human umbilical vein endothelial cells (HUVECs) as model system for endothelial cells and human placental trophoblasts (TBs), compares the effects to the putative anti-inflammatory lidocaine and investigates the partially alleviating impact of the anti-inflammatory corticosteroid dexamethasone.