Open AccessBaseline Functional Connectivity Predicts Connectivity Changes Due to a Small Dose of Midazolam in Older Adults
Author(s) -
Michael A. Frölich,
David M. White,
Nina Kraguljac,
Adrienne C. Lahti
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004385
Subject(s) - midazolam , medicine , context (archaeology) , benzodiazepine , resting state fmri , hypnotic , repeatable battery for the assessment of neuropsychological status , anesthesia , observational study , affect (linguistics) , cognition , neuropsychology , sedation , psychology , psychiatry , radiology , paleontology , receptor , biology , communication
In the perioperative context, benzodiazepines are widely used as anxiolytics. They affect cognition in general, but it is unclear whether the effects of a small dose of the short-acting benzodiazepine midazolam can be assessed objectively. To address this scientific question, we conducted a prospective observational study in adults 55-73 years of age. Using both validated psychometric and functional imaging techniques, we determined whether a 2-mg intravenous (IV) dose of midazolam affects cognitive function.