Open AccessCoagulation Factor Levels and Underlying Thrombin Generation Patterns in Adult Extracorporeal Membrane Oxygenation Patients
Author(s) -
Michael Mazzeffi,
Erik Strauss,
Michael J. Meyer,
Shaheer Hasan,
Miranda Judd,
Ezeldeen Abuelkasem,
Jonathan H. Chow,
Veendwani,
Paul McCarthy,
Kenichi A. Tanaka
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004275
Subject(s) - extracorporeal membrane oxygenation , antithrombin , medicine , protein c , thrombin generation , thrombin , anticoagulant , tissue factor , thrombomodulin , heparin , coagulation , cardiology , anesthesia , endocrinology , platelet
There is a paucity of data on the underlying procoagulant-anticoagulant balance during extracorporeal membrane oxygenation (ECMO). We hypothesized that adult ECMO patients would have an imbalance between procoagulant and anticoagulant factors, leading to an abnormal underlying thrombin generation (TG) pattern.