Open AccessMethylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain
Author(s) -
Zerong You,
Weihua Ding,
Jason T Doheny,
Shiqian Shen,
Jinsheng Yang,
Liuyue Yang,
Lucy Chen,
Shengmei Zhu,
Jianren Mao
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004273
Subject(s) - medicine , analgesic , morphine , chronic pain , opioid , anesthesia , nociception , methylphenidate , pharmacology , conditioned place preference , physical therapy , receptor , attention deficit hyperactivity disorder , psychiatry
The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse, and addiction. Central dopamine (DA) dysfunction contributes to the chronicity of pain and a decreased opioid analgesic effect. Methylphenidate (MPH/Ritalin) enhances central DA function by inhibiting DA reuptake. In this study, we used a rat model of chronic pain to examine whether combination of MPH with morphine (MOR) would improve the MOR analgesic effect under a chronic pain condition.