Open AccessChronic Calcineurin Inhibition via Cyclosporine A Impairs Visuospatial Learning After Isoflurane Anesthesia
Author(s) -
Iris Speigel,
M. Christopher,
Edyta K. Bichler,
Jennifer Gooch,
Paul S. García
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004183
Subject(s) - calcineurin , isoflurane , medicine , anesthetic , morris water navigation task , anesthesia , pharmacology , barnes maze , neuroscience , endocrinology , hippocampal formation , psychology , transplantation , spatial learning
Clinical studies implicate the perioperative period in cognitive complications, and increasing experimental evidence shows that the anesthetic agents can affect neuronal processes that underpin learning and memory. Calcineurin, a Ca-dependent phosphatase critically involved in synaptic plasticity, is activated after isoflurane exposure, but its role in the neurological response to anesthesia is unclear.