Open AccessIncisional Injury Modulates Morphine Reward and Morphine-Primed Reinstatement: A Role of Kappa Opioid Receptor Activation
Author(s) -
Chinwe A. Nwaneshiudu,
Xiaoshuang Shi,
J. David Clark
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004142
Subject(s) - morphine , medicine , κ opioid receptor , conditioned place preference , dynorphin , nucleus accumbens , opioid , pharmacology , anesthesia , receptor , opioid peptide
Persistent use of prescription opioids beyond the period of surgical recovery is a large part of a public health problem linked to the current opioid crisis in the United States. However, few studies have been conducted to examine whether morphine reward is influenced by acute pain and injury.