Open AccessEffects of Dexmedetomidine on Myocardial Repolarization in Children Undergoing General Anesthesia: A Randomized Controlled Trial
Author(s) -
Matthias Görges,
Elizabeth D. Sherwin,
Andrew Poznikoff,
Nicholas West,
Sonia M. Brodie,
Simon Whyte
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004135
Subject(s) - medicine , dexmedetomidine , anesthesia , qt interval , torsades de pointes , repolarization , heart rate , bolus (digestion) , confidence interval , electrocardiography , blood pressure , sedation , electrophysiology
Dexmedetomidine is a highly selective α2-adrenergic agonist, which is increasingly used in pediatric anesthesia and intensive care. Potential adverse effects that have not been rigorously evaluated in children include its effects on myocardial repolarization, which is important given that the drug is listed as a possible risk factor for torsades de pointes. We investigated the effect of 3 different doses of dexmedetomidine on myocardial repolarization and transmural dispersion in children undergoing elective surgery with total IV anesthesia.