Open AccessProliferator-Activated Receptor-Gamma Coactivator-1α Haploinsufficiency Promotes Pain Chronification After Burn Injury
Author(s) -
Jiamin Miao,
Xue Zhou,
Weihua Ding,
Zerong You,
Jason T Doheny,
Wei Mei,
Qian Chen,
Jianren Mao,
Shiqian Shen
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004086
Subject(s) - haploinsufficiency , burn injury , inflammation , medicine , mitochondrial biogenesis , hypermetabolism , coactivator , chronic pain , neuropathic pain , polytrauma , nerve injury , receptor , anesthesia , endocrinology , mitochondrion , surgery , biology , phenotype , psychiatry , gene , transcription factor , biochemistry , microbiology and biotechnology
Tissue injuries such as surgery and trauma are usually accompanied by simultaneous development of acute pain, which typically resolves along with tissue healing. However, in many cases, acute pain does not resolve despite proper tissue repair; rather, it transitions to chronic pain. In this study, we examined whether proliferator-activated receptor-gamma coactivator-1α (PGC-1α), a master regulator of mitochondria biogenesis, is implicated in pain chronification after burn injury in mice.