Open AccessMinocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus
Author(s) -
Jiajia Dai,
Zhuofeng Ding,
Jie Zhang,
Wei Xu,
Qulian Guo,
Wangyuan Zou,
Yunchuan Xiong,
Yingqi Weng,
Yong Yang,
Sisi Chen,
Junming Zhang,
Zongbin Song
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004063
Subject(s) - microglia , minocycline , medicine , hippocampus , proinflammatory cytokine , bone cancer , cancer , inflammation , chemistry , antibiotics , biochemistry
Pain and depression are highly prevalent symptoms in cancer patients. They tend to occur simultaneously and affect each other and share biological pathways and neurotransmitters. In this study, we investigated the roles of microglia in the hippocampus in the comorbidity of bone cancer pain and depressive-like behaviors in an animal model of bone cancer pain.