Open AccessEarly Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema
Author(s) -
Vaskar Das,
Jeffrey S. Kroin,
Mario Moric,
Robert J. McCarthy,
Asokumar Buvanendran
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004057
Subject(s) - medicine , metformin , saline , allodynia , edema , anesthesia , neuropathic pain , peripheral edema , bone healing , endocrinology , surgery , hyperalgesia , diabetes mellitus , adverse effect , nociception , receptor
Metformin, an adenosine monophosphate (AMP)-activated protein kinase activator, as well as a common drug for type 2 diabetes, has previously been shown to decrease mechanical allodynia in mice with neuropathic pain. The objective of this study is to determine if treatment with metformin during the first 3 weeks after fracture would produce a long-term decrease in mechanical allodynia and improve a complex behavioral task (burrowing) in a mouse tibia fracture model with signs of complex regional pain syndrome.