Open AccessMaternal Noninfectious Fever Enhances Cell Proliferation and Microglial Activation in the Neonatal Rat Dentate Gyrus
Author(s) -
Carlo Pancaro,
Julie Boulanger-Bertolus,
Scott Segal,
Chris Watson,
Indiana Charles,
George A. Mashour,
James E. Marchand
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000004051
Subject(s) - dentate gyrus , glial fibrillary acidic protein , microglia , hippocampus , offspring , medicine , endocrinology , cell growth , andrology , immunology , biology , immunohistochemistry , pregnancy , inflammation , biochemistry , genetics
Fever and increased maternal interleukin-6 (IL-6) plasma levels in labor are associated with an increased risk of adverse events in offspring, including neonatal seizures, cerebral palsy, and low intelligence scores at school age. However, the neural changes in the neonate that might mediate the adverse effects of maternal noninfectious fever are not fully characterized. This study was designed to test the hypothesis that induced maternal noninfectious fever alters neonatal neural progenitor cell proliferation and enhances microglial activation in the rat dentate gyrus of the hippocampus.