Open AccessEfficacy of Intrathecal Fentanyl for Cesarean Delivery: A Systematic Review and Meta-analysis of Randomized Controlled Trials With Trial Sequential Analysis
Author(s) -
Vishal Uppal,
Susanne Retter,
Margaret Casey,
Sushil F. Sancheti,
Kara Matheson,
Dolores M. McKeen
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003975
Subject(s) - medicine , fentanyl , anesthesia , bupivacaine , randomized controlled trial , relative risk , meta analysis , cochrane library , nausea , vomiting , analgesic , clinical trial , surgery , confidence interval
Fentanyl and morphine are the 2 most commonly added opioids to bupivacaine for spinal anesthesia during cesarean delivery. Numerous clinical trials have assessed efficacy and safety of different doses of fentanyl added to intrathecal bupivacaine for spinal anesthesia, yet its benefit, harm, and optimal dose remain unclear. This study aimed to systematically review the evidence of the efficacy of fentanyl when added to intrathecal bupivacaine alone and when added to bupivacaine with morphine for spinal anesthesia during cesarean delivery.