Open AccessGlycocalyx Degradation Is Independent of Vascular Barrier Permeability Increase in Nontraumatic Hemorrhagic Shock in Rats
Author(s) -
Philippe Guerci,
Bülent Ergin,
Zühre Uz,
Yasin Ince,
Manfred Westphal,
Michal Heger,
Can İnce
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003918
Subject(s) - glycocalyx , medicine , vascular permeability , hydroxyethyl starch , microcirculation , resuscitation , intravital microscopy , edema , mean arterial pressure , evans blue , shock (circulatory) , anesthesia , blood pressure , pathology , heart rate , immunology
Glycocalyx shedding after traumatic hemorrhagic or septic shock, as well as different resuscitation fluids, has been causally linked to increased vascular barrier permeability (VBP) resulting in tissue edema. In nontraumatic hemorrhagic shock (NTHS), it remains questionable whether glycocalyx degradation in itself results in an alteration of VBP. The composition of fluids can also have a modulatory effect on glycocalyx shedding and VBP. We hypothesized that the shedding of the glycocalyx during NTHS has little effect on VBP and that the composition of fluids can modulate these effects.