Open AccessDexamethasone Is Superior to Dexmedetomidine as a Perineural Adjunct for Supraclavicular Brachial Plexus Block: Systematic Review and Indirect Meta-analysis
Author(s) -
Éric Albrecht,
Leon Vorobeichik,
Alain Jacot-Guillarmod,
Nicolas Fournier,
Faraj W. Abdallah
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003860
Subject(s) - medicine , dexmedetomidine , anesthesia , meta analysis , sedation , dexamethasone , relative risk , confidence interval , randomized controlled trial , brachial plexus , nerve block , surgery
Both dexamethasone and dexmedetomidine are effective peripheral nerve block (PNB) perineural adjuncts that prolong block duration. However, each is associated with side effects. With paucity of head-to-head comparisons of these adjuncts, the question of the best adjunct to mix with local anesthetics (LA) for PNB is unanswered. This meta-analysis aims to inform current practice and future research by identifying the superior adjunct by comparing dexamethasone and dexmedetomidine.