Open AccessDexmedetomidine-Mediated Prevention of Renal Ischemia-Reperfusion Injury Depends in Part on Cholinergic Anti-Inflammatory Mechanisms
Author(s) -
Jingyi Ma,
Qian Chen,
Juanjuan Li,
Hailin Zhao,
Emma Mi,
Yan Chen,
Bin Yi,
Jiaolin Ning,
Daqing Ma,
Kun Lü,
Jianteng Gu
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003820
Subject(s) - medicine , dexmedetomidine , cholinergic , ischemia , reperfusion injury , kidney , endocrinology , atipamezole , acetylcholine , agonist , inflammation , vagotomy , renal ischemia , pharmacology , anesthesia , receptor , blood pressure , heart rate , sedation , medetomidine
Organ ischemia-reperfusion injury often induces local and systemic inflammatory responses, which in turn worsen organ injury. These inflammatory responses can be regulated by the central nervous system, particularly by the vagal nerve and nicotinic acetylcholine receptors, which are the key components of cholinergic anti-inflammatory pathway. Activation of the cholinergic anti-inflammatory pathway can suppress excessive inflammatory responses and be a potential strategy for prevention of ischemia-reperfusion injury of organs including the kidney.