Open AccessPharmacokinetics of Dexmedetomidine in Infants and Children After Orthotopic Liver Transplantation
Author(s) -
Mihaela Damian,
Gregory B. Hammer,
Mohammed H. Elkomy,
Adam Frymoyer,
David R. Drover,
Felice Su
Publication year - 2020
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003761
Subject(s) - medicine , dexmedetomidine , pharmacokinetics , liver transplantation , volume of distribution , transplantation , population , anesthesia , confidence interval , intensive care unit , gastroenterology , sedation , environmental health
Dexmedetomidine (DEX) is a sedative and analgesic medication that is frequently used postoperatively in children after liver transplantation. Hepatic dysfunction, including alterations in drug clearance, is common immediately after liver transplantation. However, the pharmacokinetics (PK) of DEX in this population is unknown. The objective of this study was to determine the PK profile of DEX in children after liver transplantation.