Open AccessThe GCs-SGK1-ATP Signaling Pathway in Spinal Astrocytes Underlied Presurgical Anxiety-Induced Postsurgical Hyperalgesia
Author(s) -
Zuoxia Zhang,
Hao Wu,
Yue Liu,
Xiaoping Gu,
Wei Zhang,
Zhengliang Ma
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003682
Subject(s) - medicine , corticosterone , anesthesia , hyperalgesia , mifepristone , glucocorticoid , endocrinology , receptor , nociception , pregnancy , biology , hormone , genetics
Patients undergoing surgery often feel anxious. Accumulating evidence indicated that presurgical anxiety was related to the more severe postsurgical pain. An animal model was established that exposed Sprague-Dawley rats to a single-prolonged stress (SPS) procedure to induce presurgical anxiety-like behaviors. The experiment revealed that presurgical anxiety not only aggravated but also prolonged postsurgical pain. However, the underlying mechanisms were unknown.