Open AccessRemifentanil Induces Cardio Protection Against Ischemia/Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress Through the Maintenance of Zinc Homeostasis
Author(s) -
Mingwei Sheng,
Ge Zhang,
Jiannan Wang,
Qing Yang,
Huanhuan Zhao,
Xinxin Cheng,
Zhelong Xu
Publication year - 2018
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003414
Subject(s) - medicine , ischemia , hypoxia (environmental) , endoplasmic reticulum , reperfusion injury , homeostasis , pharmacology , unfolded protein response , endocrinology , microbiology and biotechnology , biology , chemistry , organic chemistry , oxygen
Although it is well known that remifentanil (Rem) elicits cardiac protection against ischemia/reperfusion (I/R) injury, the underlying mechanism remains unclear. This study tested if Rem can protect the heart from I/R injury by inhibiting endoplasmic reticulum (ER) stress through the maintenance of zinc (Zn) homeostasis.