Open AccessPopulation Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total Knee Replacement Surgery
Author(s) -
Usha Gurunathan,
Suzanne L. Parker,
R. James Maguire,
Dale Ramdath,
Manu Bijoor,
Steven C. Wallis,
Jason A. Roberts
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003377
Subject(s) - ketorolac , ketorolac tromethamine , medicine , pharmacokinetics , anesthesia , arthroplasty , volume of distribution , ropivacaine , surgery , urology , analgesic
Ketorolac tromethamine has been used for joint infiltration by the orthopedic surgeons as a part of postoperative multimodal analgesia. The objective of this study is to investigate the pharmacokinetic properties of S (-) and R (+) enantiomers of ketorolac in adult patients undergoing total hip (THA) and knee arthroplasty (TKA).