Open AccessRepeated Morphine Prolongs Postoperative Pain in Male Rats
Author(s) -
Peter M. Grace,
Erika L. Galer,
Keith A. Strand,
Kaci Corrigan,
Debra Berkelhammer,
Steven F. Maier,
Linda R. Watkins
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003345
Subject(s) - medicine , morphine , laparotomy , anesthesia , perioperative , neuropathic pain , analgesic , hyperalgesia , nociception , surgery , receptor
Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitability in the spinal dorsal horn. Herein, we tested whether perioperative morphine could similarly prolong postoperative pain in male rats.