Open AccessAnesthetics Influence Mortality in a Drosophila Model of Blunt Trauma With Traumatic Brain Injury
Author(s) -
Julie A Fischer,
Zachariah P. G. Olufs,
Rebeccah J. Katzenberger,
David A. Wassarman,
Misha Perouansky
Publication year - 2018
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000002906
Subject(s) - isoflurane , medicine , sevoflurane , anesthesia , traumatic brain injury , blunt , surgery , psychiatry
Exposure to anesthetics is common in the majority of early survivors of life-threatening injuries. Whether and to what degree general anesthetics influence outcomes from major trauma is unknown. Potential confounding effects of general anesthetics on outcome measures are usually disregarded. We hypothesized that exposure to isoflurane or sevoflurane modulates the outcome from blunt trauma with traumatic brain injury (bTBI).