Open AccessUsefulness of Basophil Activation Tests for Diagnosis of Sugammadex-Induced Anaphylaxis
Author(s) -
Tatsuo Horiuchi,
Akihiko Yokohama,
Masaki Orihara,
Yukinari Tomita,
Akihiro Tomioka,
Nagahide Yoshida,
Kenichiro Takahashi,
Shigeru Saito,
Tomonori Takazawa
Publication year - 2018
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000002879
Subject(s) - sugammadex , medicine , anaphylaxis , basophil activation , rocuronium , anesthesia , gold standard (test) , confidence interval , allergy , immunology , antibody , immunoglobulin e , basophil , propofol
Sugammadex is used to reverse the effects of neuromuscular blocking agents in many cases of general anesthesia. However, there are several reports of anaphylaxis after its use. Skin testing is the gold standard for detecting the causative agent of anaphylaxis. However, due to the lack of validated protocols for skin testing with sugammadex, the diagnostic accuracy might be inadequate. Recently, the basophil activation test (BAT) has been established as a tool to detect the causative agent of anaphylaxis with high sensitivity and specificity. However, few studies have investigated the utility of the BAT for sugammadex-induced anaphylaxis.