Open Accessα-Asarone Alleviated Chronic Constriction Injury–Induced Neuropathic Pain Through Inhibition of Spinal Endoplasmic Reticulum Stress in an Liver X Receptor–Dependent Manner
Author(s) -
Yulong Gui,
Aiyuan Li,
Jie Zhang,
Li Guan,
Xiuxiu Ruan,
Qulian Guo,
Wangyuan Zou
Publication year - 2018
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000002792
Subject(s) - neuropathic pain , medicine , anesthesia , saline , endoplasmic reticulum , pharmacology , hyperalgesia , nociception , receptor , chemistry , biochemistry
Neuropathic pain is an intractable and complex disease. Recent studies have shown a close relationship between endoplasmic reticulum (ER) stress and neuropathic pain. Here, we investigated the effect of α-asarone, an ER stress inhibitor, on chronic constriction injury (CCI)-induced neuropathic pain.