Open AccessImprovement of the Elevated Tryptase Criterion to Discriminate IgE- From Non–IgE-Mediated Allergic Reactions
Author(s) -
Gabriel Gastaminza,
Alberto Lafuente,
M. J. Goikoetxea,
Carmen D’Amelio,
Amalia Bernad-Alonso,
Olga Vega,
Juan Ambrosio Martinez-Molina,
Marta Ferrer,
Jorge M. NúñezCórdoba
Publication year - 2018
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000002656
Subject(s) - immunoglobulin e , tryptase , medicine , immunology , anaphylaxis , allergy , quartile , antibody , mast cell , confidence interval
Differentiating between immunoglobulin E (IgE)-dependent and IgE-independent hypersensitivity reactions may improve the etiologic orientation and clinical management of patients with allergic reactions in the anesthesia setting. Serum tryptase levels may be useful to discriminate the immune mechanism of allergic reactions, but the diagnostic accuracy and optimal cutpoint remain unclear.We aimed to compare the diagnostic accuracy of tryptase during reaction (TDR) alone and the TDR/basal tryptase (TDR/BT) ratio for discriminating IgE- from non-IgE-mediated allergic reactions, and to estimate the best cut point for these indicators.