Open AccessNoninfectious Fever in the Near-Term Pregnant Rat Induces Fetal Brain Inflammation
Author(s) -
Scott Segal,
Carlo Pancaro,
Iwona Bonney,
James E. Marchand
Publication year - 2017
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000002479
Subject(s) - medicine , fetus , neuroinflammation , microglia , inflammation , gestation , hippocampal formation , pregnancy , anesthesia , andrology , pathology , biology , genetics
Women laboring with epidural analgesia experience fever much more frequently than do women who chose other forms of analgesia, and maternal intrapartum fever is associated with numerous adverse consequences, including brain injury in the fetus. We developed a model of noninfectious inflammatory fever in the near-term pregnant rat to simulate the pathophysiology of epidural-associated fever and hypothesized that it would produce fetal brain inflammation.