Open AccessPerfluorocarbon Administration During Cardiopulmonary Bypass in Rats: An Inflammatory Link to Adverse Outcome?
Author(s) -
Fellery de Lange,
Kenji Yoshitani,
Alan D. Proia,
G. Burkhard Mackensen,
Hilary P. Grocott
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/01.ane.0000297439.90773.c7
Subject(s) - medicine , cardiopulmonary bypass , anesthesia , saline , tumor necrosis factor alpha , adverse effect , cytokine , proinflammatory cytokine , inflammatory response , cardiac surgery , inflammation , surgery
Perfluorocarbon (PFC) emulsions are artificial oxygen carriers that have been shown to attenuate the effects of air embolism. Cerebral air embolism, known to occur during cardiopulmonary bypass (CPB), may contribute to adverse cerebral outcomes after cardiac surgery. We designed this study to evaluate the effect of a 60% PFC emulsion (perfluoro-tert-butylcyclohexane; PTBCH) on the inflammatory response and neurocognitive outcome of rats after CPB.