Open AccessThe Influence of Hemorrhagic Shock on the Minimum Alveolar Anesthetic Concentration of Isoflurane in a Swine Model
Author(s) -
Tadayoshi Kurita,
Kazuhide Takata,
Masahiro Uraoka,
Koji Morita,
Yoshimitsu Sanjo,
Takasumi Katoh,
Shigehito Sato
Publication year - 2007
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/01.ane.0000287252.39383.17
Subject(s) - medicine , anesthesia , isoflurane , (+) naloxone , shock (circulatory) , resuscitation , anesthetic , endorphins , hemodynamics , endogenous opioid , blood volume , minimum alveolar concentration , opioid , receptor
Although hemorrhagic shock decreases the minimum alveolar concentration (MAC) of inhaled anesthetics, it minimally alters the electroencephalographic (EEG) effect. Hemorrhagic shock also induces the release of endorphins, which are naturally occurring opioids. We tested whether the release of such opioids might explain the decrease in MAC.