Open AccessEvaluation of the Neuroprotective Effects of S(+)-Ketamine During Open-Heart Surgery
Author(s) -
W. Nagels,
Roland Demeyere,
J. Van Hemelrijck,
E. Vandenbussche,
K. Gijbels,
E. Vandermeersch
Publication year - 2004
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/01.ane.0000117227.00820.0c
Subject(s) - medicine , ketamine , remifentanil , propofol , neuroprotection , anesthesia , neurocognitive , cardiac surgery , surgery , cardiopulmonary bypass , cognition , psychiatry
We compared the effect of S(+)-ketamine to remifentanil, both in combination with propofol, on the neurocognitive outcome after open-heart surgery in 106 patients. A battery of neurocognitive tests was administered before surgery and 1 and 10 wk after surgery. Fourteen patients (25%) in the control group and 10 patients (20%) in the S(+)-ketamine group had 2 or more tests with a cognitive deficit (decline by at least one preoperative SD of that test in all patients) 10 wk after surgery (P = 0.54). Z-scores were calculated for all tests. No significantly better performance could be detected in the S(+)-ketamine group, except for the Trailmaking B test 10 wk after surgery. We conclude that S(+)-ketamine offers no greater neuroprotection compared with remifentanil during open-heart surgery.