Open AccessA Suspected Case of Delayed Onset Malignant Hyperthermia with Desflurane Anesthesia
Author(s) -
Thomas J. Papadimos,
Mohamad Almasri,
James C. Padgett,
Joanne E. Rush
Publication year - 2004
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/01.ane.0000097172.44227.0d
Subject(s) - dantrolene , malignant hyperthermia , desflurane , medicine , anesthetic , ryanodine receptor , anesthesia , volatile anesthetic , anesthetic agent , receptor , calcium
Desflurane has been identified as a weak triggering anesthetic of malignant hyperthermia that, in the absence of succinylcholine, may produce a delayed onset of symptoms. The prolonged interval after exposure may occur more than 6 h after the induction of anesthesia. The unintended underdosing of this patient with dantrolene and the prompt reversal of symptoms may be an attribute of the genetic expression of a weak triggering volatile anesthetic such as desflurane.