A Suspected Case of Delayed Onset Malignant Hyperthermia with Desflurane Anesthesia | Zendy

Thomas J. Papadimos | Zendy; Mohamad Almasri | Zendy; James C. Padgett | Zendy; Joanne E. Rush | Zendy

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A Suspected Case of Delayed Onset Malignant Hyperthermia with Desflurane Anesthesia

Author(s) -

Thomas J. Papadimos,

Mohamad Almasri,

James C. Padgett,

Joanne E. Rush

Publication year - 2004

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/01.ane.0000097172.44227.0d

Subject(s) - dantrolene , malignant hyperthermia , desflurane , anesthetic , ryanodine receptor , anesthesia , medicine , volatile anesthetic , hyperthermia , receptor , calcium

Desflurane has been identified as a weak triggering anesthetic of malignant hyperthermia that, in the absence of succinylcholine, may produce a delayed onset of symptoms. The prolonged interval after exposure may occur more than 6 h after the induction of anesthesia. The unintended underdosing of this patient with dantrolene and the prompt reversal of symptoms may be an attribute of the genetic expression of a weak triggering volatile anesthetic such as desflurane.

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