Open AccessCardiovascular Changes During Continuous Hyperthermic Peritoneal Perfusion
Author(s) -
Nobuaki Shime,
Mitsuyoshi Lee,
Tetsuo Hatanaka
Publication year - 1994
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-199405000-00018
Subject(s) - medicine , anesthesia , cardiac index , hyperthermia , vascular resistance , cardiac output , oxygenation , perfusion , hemodynamics , methoxamine , blood pressure , cardiology , agonist , receptor
Changes in blood temperature, hemodynamics, and oxygen transport were evaluated in 11 patients during continuous hyperthermic peritoneal perfusion (CHPP), a technique in which the peritoneal cavity is perfused continuously with heated solution to treat intraperitoneal cancer. CHPP was undertaken 46.8 min after the resection of cancer. Blood temperature, measured with a thermistor of a pulmonary artery catheter, reached 39.2 degrees C. Heart rate increased to 100.7 +/- 21.4 bpm (mean +/- SD) and the cardiac index to 4.61 +/- 0.80 L.min-1.m-2. Mean arterial pressure decreased to 75.5 +/- 10.8 mm Hg and systemic vascular resistance index to 1239 +/- 394 dynes.s.cm-5.m2. Oxygen consumption greatly increased to 139.1 +/- 35.2 mL.min-1.m-2, concurrently with a smaller increase in oxygen delivery to 619.7 +/- 83.7 mL.min-1.m-2 and a slight increase in oxygen extraction. Pulmonary oxygenation capacity was also disturbed. Although these cardiovascular changes were mainly due to systemic hyperthermia, other changes may be caused by splanchnic heating, abdominal distention, and pharmacologic action of methoxamine, propranolol, diltiazem, and fentanyl.