
A Comparison of the Effects of Propofol and Nitrous Oxide on the Electroencephalogram in Epileptic Patients During Conscious Sedation for Dental Procedures
Author(s) -
V. L. B. Oei-Lim,
Cor J. Kalkman,
E. C. M. Bouvy-Berends,
Eelco F. Posthumus Meyjes,
Peter C. Makkes,
D.M.E. Vermeulen-Cranch,
J. A. Odoom,
Harry B. van Wezel,
J. G. Bovill
Publication year - 1992
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-199211000-00009
Subject(s) - propofol , nitrous oxide , medicine , sedation , anesthesia , sedative , epilepsy , anesthetic , ictal , electroencephalography , adverse effect , pharmacology , psychiatry
The influence of sedative doses of propofol or nitrous oxide on the electroencephalogram was studied in 11 mentally handicapped patients with treated epilepsy undergoing dental procedures. At one session, propofol was titrated to achieve conscious sedation. The mean (+/- SD) dose requirements were 5.5 +/- 1.1 mg.kg-1.h-1. In six patients, the electroencephalogram was unchanged during propofol administration. In three patients, there was a decrease in epileptic activity, and in two patients, paroxysmal discharges disappeared. At another session, nitrous oxide was administered by nasal mask. The mean (+/- SD) concentration of nitrous oxide needed was 43.6% +/- 4.8%. The electroencephalogram did not change in nine patients, whereas in two patients epileptic activity decreased. There were no clinical epileptoid or other adverse manifestations during any treatment or up to 48 h thereafter. The results of the present study suggest that propofol or nitrous oxide can be administered in subanesthetic doses for conscious sedation in mentally handicapped patients with treated epilepsy.