Open AccessEffects of Hydralazine and Prostaglandin E1 on Regional Myocardial Function in the Ischemic Canine Heart
Author(s) -
Shigeho Morita,
Hisato Takahashi,
Michihito Kono,
Yukihiko Uno,
Midori Ozawa,
Toshiro Sato
Publication year - 1991
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-199101000-00021
Subject(s) - medicine , hydralazine , cardiology , papaverine , cardiac index , cardiac function curve , hemodynamics , stroke volume , ischemia , prostaglandin , prostaglandin e1 , anesthesia , blood pressure , cardiac output , heart rate , heart failure
The effects of hydralazine and prostaglandin E1 on regional myocardial function were studied in dogs. Sixteen dogs were randomly assigned to one of two drug treatment groups of eight dogs each. The first group (G1) was treated with 0.4 mg/kg hydralazine administered as a bolus. The second group (G2) received prostaglandin E1 given as an infusion for a total dose of 0.8 micrograms/kg. Regional myocardial function was assessed through the measurement of myocardial segment shortening during systole. We call this index percent systolic shortening (%SS). An ischemic heart preparation was created by partial occlusion of coronary blood flow. The degree of induced ischemia was determined by following the reduction in %SS. Hydralazine reduced %SS of the ischemic myocardium while increasing the cardiac index, stroke volume index, and coronary blood flow. Prostaglandin E1 increased %SS, cardiac index, and stroke volume index in the ischemic heart preparation. Hydralazine, therefore, induced dissociation between global ventricular function and regional myocardial function whereas prostaglandin E1 did not. The present findings emphasize that evaluation of vasoactive drugs should consider their effects on regional myocardial function as well as on global hemodynamics.