Open AccessClinical Pharmacokinetics of Carbonated Local Anesthetics III
Author(s) -
Radha Sukhani,
Alon P. Winnie
Publication year - 1989
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-198902000-00003
Subject(s) - medicine , lidocaine , anesthesia , lidocaine hydrochloride , pharmacokinetics , cmax , brachial plexus block , venous blood , brachial plexus , pharmacology
To compare serum levels of lidocaine resulting from 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride, the two salts were administered to ten healthy adult patients undergoing upper extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both the solutions just prior to injection, and, following performance of the blocks, venous blood samples were drawn at 3, 5, 10, 15, 20, 30, 60 and 120 minutes. The concentration of lidocaine tended to rise more rapidly and to achieve higher levels in the first 10 minutes following injection of the carbonated lidocaine. However, no significant differences were found in the parameters of Cmax, Tmax or AUC for the two salts, and the serum levels in both groups at all times were well below the levels known to produce systemic toxicity. Therefore, while previous studies appear to indicate that the carbonate salt enhances diffusion, penetration, and uptake of neural tissues as compared with the hydrochloride salt, the present study indicates that vascular uptake is not similarly affected.