Open AccessHemodynamic and Hepatic Effects of Methohexital Infusion during Nitrous Oxide Anesthesia in Humans
Author(s) -
C. PrysRoberts,
J.W. Sear,
J. M. Low,
K. C. Phillips,
Jorge Dagnino
Publication year - 1983
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-198303000-00005
Subject(s) - medicine , methohexital , anesthesia , hemodynamics , tracheal intubation , cardiac output , nitrous oxide , inhalation , vascular resistance , intubation , mean arterial pressure , blood pressure , laryngoscopy , ventilation (architecture) , heart rate , propofol , mechanical engineering , engineering
The hemodynamic effects of methohexital, at infusion rates of 60-65 and 120 micrograms/kg/min with concomitant inhalation of 67% nitrous oxide in oxygen, have been studied during spontaneous and controlled ventilation in 8 patients. Under most of the conditions studied methohexital infusion anesthesia was associated with lower arterial pressure (-13% to -33%) than in the awake state, decreased cardiac output (-26% to -38%), and increased systemic vascular resistance (+5% to +37%) during surgery, but also with decreased cardiac output (-25%) and decreased systemic vascular resistance (-13%) during anesthesia without surgery. The higher infusion rate was not associated with decreases in arterial pressure or cardiac output during either spontaneous or controlled ventilation. The hemodynamic response to laryngoscopy and intubation was poorly suppressed by methohexital in that peak arterial pressures exceeded the preanesthetic values by 33%. No evidence of impaired hepatocellular function was found after infusions of methohexital lasting up to 4 h.