Open AccessEffects of Diazepam on Succinylcholine-Induced Myalgia, Potassium Increase, Creatine Phosphokinase Elevation, and Relaxation
Author(s) -
M.P.H. Mark J. Eisenberg,
Sharon Balsley,
Ronald L. Katz
Publication year - 1979
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-197907000-00011
Subject(s) - fasciculation , medicine , diazepam , creatine kinase , myalgia , anesthesia , muscle relaxation , potassium , muscle relaxant , muscle spasm , hypokalemia , chemistry , organic chemistry
Diazepam in a dose of 0.05 mg/kg was studied to determine its effect on a subsequently administered dose of 1 mg/kg of succinylcholine. This dose of diazepam prior to succinylcholine (1) significantly diminished the incidence of postoperative muscle pain; (2) decreased the usual increase in serum potassium; (3) did not prevent the rise in creatine phosphokinase; (4) reduced the incidence of muscle fasciculation; and (5) did not affect the magnitude or duration of the succinylcholine neuromuscular block. It was concluded that diazepam had several advantages over d-tubocurarine in the prevention of succinylcholine-induced muscle pain.