Open AccessEffects of pH on Protein Binding of Lidocaine
Author(s) -
Burney Rg,
CA DiFazio,
JA Foster
Publication year - 1978
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-197807000-00019
Subject(s) - lidocaine , medicine , plasma protein binding , anesthesia , pharmacology , plasma concentration
Protein binding of lidocaine (2.5, 5, 10, and 20 microgram/ml in fresh plasma was studied from pH 5.6 to pH 9.8. Percent binding of lidocaine was inversely related to hydrogen-ion and lidocaine concentrations.