Open AccessThe Anesthetic Potency of Lidocaine in the Rat
Author(s) -
Cosmo A. DiFazio,
James R. Niederlehner,
Robert G. Burney
Publication year - 1976
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-197611000-00016
Subject(s) - lidocaine , medicine , anesthetic , potency , anesthesia , local anesthetic , cyclopropane , anesthetic effect , topical anesthetic , in vitro , biochemistry , chemistry , ring (chemistry) , organic chemistry
The anesthetic effect of lidocaine was evaluated in rats by determining the change in anesthetic requirement of cyclopropane MAC that was produced by blood concentrations of lidocaine in the clinically useful range. A linear reduction in anesthetic requirement was produced with concentrations up to 1 mug/ml. Further increases in lidocaine up to 5.5 mug/ml resulted in no further decrease in cyclopropane requirement. Lidocaine was found to contribute a maximum MAC fraction of 0.4.