Open AccessThe Effect of EnfIurane, lsofIurane, FIuroxene, Methoxyflurane and Diethyl Ether Anesthesia on Ouabain Tolerance in the Dog
Author(s) -
Anthony D. Ivankovich,
David J. Miletich,
Ronald K. Grossman,
Ronald F. Albrecht,
Adel A. El-Etr,
Vincent J. Cairoli
Publication year - 1976
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/00000539-197605000-00017
Subject(s) - methoxyflurane , medicine , diethyl ether , ouabain , anesthesia , ether , halothane , chromatography , organic chemistry , sodium , chemistry
Digitalis tolerance in dogs anesthetized with enflurane, isoflurane, fluroxene, methoxyflurane, and diethyl ether was compared with that in dogs anesthetized with pentobarbital. Ouabain dosage needed to cause ventricular tachycardia was significantly higher than that of pentobarbital with all agents except fluroxene, as was the LD50. The relative potency of these anesthetics in converting ouabain-induced ventricular tachycardia to sinus rhythm, in order of descending effectiveness, was: diethyl ether, methoxyflurane, enflurane, fluroxene, isoflurane, pentobarbital.