Open AccessAssociation of Thrombin Generation With Leukocyte Inflammatory Profile in Patients With Acute Ischemic Stroke
Author(s) -
Sarina Falcione,
Danielle Munsterman,
Twinkle Joy,
Joseph KamtchumTatuene,
Gina Sykes,
Glen C. Jickling
Publication year - 2022
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000200909
Subject(s) - thrombin , medicine , stroke (engine) , tissue factor , discovery and development of direct thrombin inhibitors , thrombomodulin , immunology , platelet , coagulation , mechanical engineering , engineering
Thrombosis is central to the pathogenesis of acute ischemic stroke, with higher thrombin generation being associated with increased stroke risk. The immune system may contribute to thrombin generation in stroke and thus may offer novel strategies for stroke prevention. This study addresses the research question regarding the relationship of thrombin generation to leukocyte gene expression in patients with acute ischemic stroke.