Open AccessInertial Gait Sensors to Measure Mobility and Functioning in Hereditary Spastic Paraplegia
Author(s) -
Martin Regensburger,
Imke Tabea Spatz,
Malte Ollenschläger,
Christine F. Martindale,
Philipp Lindeburg,
Zacharias Kohl,
Bjoern M. Eskofier,
Jochen Klucken,
Rebecca Schüle,
Stephan Klebe,
Jürgen Winkler,
Heiko Gaßner
Publication year - 2022
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000200819
Subject(s) - stride , gait , physical medicine and rehabilitation , medicine , paraplegia , gait analysis , ambulatory , spastic , spasticity , physical therapy , hereditary spastic paraplegia , cerebral palsy , spinal cord , biochemistry , chemistry , psychiatry , gene , phenotype
Hereditary spastic paraplegia (HSP) causes progressive spasticity and weakness of the lower limbs. As neurological examination and the clinical Spastic Paraplegia Rating Scale (SPRS) are subject to potential patient- and clinician-dependent bias, instrumented gait analysis bears the potential to objectively quantify impaired gait. The aim of the present study was to investigate gait cyclicity parameters by application of a mobile gait analysis system in a cross sectional cohort of HSP patients and a longitudinal fast progressing subcohort.