Open AccessProteinopathy and Longitudinal Cognitive Decline in Parkinson Disease
Author(s) -
Peter S. Myers,
John O’Donnell,
Joshua J. Jackson,
Christi. LessovSchlaggar,
Rebecca L. Miller,
Erin R. Foster,
Carlos Cruchaga,
Bruno A. Benitez,
Paul T. Kotzbauer,
Joel S. Perlmutter,
Meghan Campbell
Publication year - 2022
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000200344
Subject(s) - cognitive decline , cognition , dementia , longitudinal study , psychology , medicine , apolipoprotein e , effects of sleep deprivation on cognitive performance , amyloid (mycology) , neuroscience , disease , pathology
People with Parkinson disease (PD) commonly experience cognitive decline, which may relate to increased α-synuclein, tau, and β-amyloid accumulation. This study examines whether the different proteins predict longitudinal cognitive decline in PD.